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This trial is actively recruiting in our Southampton, Bournemouth and Weymouth Research Hubs
The Odyssey 301 - Avian Flu Trial
The Odyssey 301 Trial will study an investigational vaccine (a vaccine that is being studied), called mRNA-1018 H5, to see whether it may help protect against symptoms of pandemic flu, specifically H5N1 “bird flu”.
H5 “bird flu” is a virus that causes outbreaks in birds, particularly poultry. It has also been found in other animals such as cows. People can become infected through close contact with infected animals, their droppings, or by breathing in the virus particles in a contaminated environment.
In people, symptoms have most commonly been mild and may include eye redness/irritation, fever, cough, headache, sore throat, tiredness, and muscle aches. In some cases, people may develop more serious symptoms such as shortness of breath or difficulty breathing, confusion and seizures and may need care in a hospital.
You cannot catch bird flu by receiving this investigational vaccine.
Who can take part?
You may be able to take part if you:
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are 18 years of age or older
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are in good health (including well-controlled chronic conditions)
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have not been treated with antiviral therapies or any vaccines for the last 28 days.
Further study details
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Your participation in the Odyssey 301 Trial will last about 7 months.
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You will attend an initial screening visit, up to 4 additional clinic visits, and 4 scheduled phone calls with the clinical trial team
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You will be given 2 injections about 21 days apart, which will be either:
An investigational mRNA-1018 bird flu vaccine; OR
A placebo (contains no active ingredients
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Reasonable travel costs will be reimbursed.
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After screening, up to 4 clinic visits + 4 scheduled calls across approximately 7 months.
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Each clinic visit lasts approximately 1-3 hours.
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You will be asked to complete an electronic diary (eDiary) for 7 days after each injection
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Enrolling in this clinical trial is completely your choice. An independent safety board reviews the data regularly; you can leave the study at any time.
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Please contact you nearest hub to register your interest. Each hub's contacts details are listed on the hub pages.
Frequently asked questions
Frequently Asked Questions (FAQs)
What is health research?
All new treatments go through phases of research to ensure they are safe and effective, and any side effects kept to a minimum. The results of these studies lead to treatments which help prevent diseases and diagnose illnesses. Every study we run is different and we work with both healthy participants and patients with a specific condition. We'll explain what's involved before you decide if you want to take part.
Why is health research important?
All health research relies on people being willing to take part. Every year in the UK, thousands of people put themselves forward. For example, it was volunteers who helped turn the tide against Covid-19 by taking part in vaccine trials. Our participants are currently helping us research new treatments for infectious diseases. Our vision is to run as many studies as we can to really make a difference to people’s lives.
Why take part?
• Help save lives and improve healthcare for others
• Help develop new treatments for future generations
• If you have an illness or condition, you might be able to try a new treatment
• Your health may be monitored more regularly
• Your time and expenses reimbursed (rate vary by study)
What if I still feel a little unsure?
That’s ok. Our team is here to help. We want you to be informed and supported at every stage, and we promise to give you study-specific information which is easy to understand. Your visits will take place at your closest hub. You will be seen by our specialist research team made up of doctors, nurses and clinical trials assistants. We will also ensure your GP is kept informed of your involvement and progress throughout the study.
"It's too easy just to let someone else step up to the plate, do the work and take the benefit. I wanted to make an effort to play my own part."
Michael – Research participant, Weymouth
